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More cleanup, more non-binary inclusion

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2020-09-17 23:57:29 -06:00
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# What is the Cause of Gender Incongruence?
Here is what we know today. If you’ve seen Jurassic Park then you may remember this scene:
Here is what we know today. If you've seen Jurassic Park then you may remember this scene:
{!{ {{import '~/img' images.jurassicpark className="card borderless center span34" alt="All vertebrate embryos are inherently female anyway. They just require an extra hormone given at the right developmental stage to make them male."}} }!}
This isn't science fiction, though it is very dumbed down. In human fetuses the gonads initially develop in a bi-potential state, meaning they can become either ovaries or testes. The SRY gene on the Y chromosome releases a protein called [Testis Determining Factor](https://en.wikipedia.org/wiki/Testis-determining_factor) (TDF). This protein then starts a chain reaction with SOX9 production (another protein), which causes the gonadal cells to form into the Sertoli and Leydig cells that make up the testes. If TDF is never produced or is interfered with then the gonad cells form into the Theca cells and follicles which comprise the ovaries.
This isn't science fiction, though it is very dumbed down. In human fetuses, the gonads initially develop in a bi-potential state, meaning they can become either ovaries or testes. The SRY gene on the Y chromosome releases a protein called [Testis Determining Factor](https://en.wikipedia.org/wiki/Testis-determining_factor) (TDF). This protein then starts a chain reaction with SOX9 production (another protein), which causes the gonadal cells to form into the Sertoli and Leydig cells that make up the testes. If TDF is never produced or is interfered with then the gonad cells form into the Theca cells and follicles which comprise the ovaries.
{!{ <div class="gutter flex" style="justify-content: center"> {{import '~/img' images.fetalgenitals className="card" caption="<a href=\"https://schoolbag.info/biology/concepts/188.html\">Source</a>" alt="Fetal development of internal sexual anatomy"}}</div> }!}
@@ -51,22 +51,22 @@ The fact is, the vast majority of the population has never been tested for genet
#### Brain Split
The prenatal brain doesn’t really start to develop until between week 12 and 24. The cerebral cortex, the thin outer layer of the brain that contains most of what we think of as consciousness, grows substantially during those periods of time. Prior to that, the structure present is more like a scaffolding, the basic parts of the nervous system necessary for bodily function. The primary sulci (the wrinkles in the cerebral cortex that allow for more surface area) [start to form at week 14](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989000/#Sec5title), well after the genitals have developed.
The prenatal brain doesn't really start to develop until between week 12 and 24. The cerebral cortex, the thin outer layer of the brain that contains most of what we think of as consciousness, grows substantially during those periods of time. Prior to that, the structure present is more like a scaffolding, the basic parts of the nervous system necessary for bodily function. The primary sulci (the wrinkles in the cerebral cortex that allow for more surface area) [start to form at week 14](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989000/#Sec5title), well after the genitals have developed.
It [has been confirmed multiple times](https://www.the-scientist.com/features/are-the-brains-of-transgender-people-different-from-those-of-cisgender-people-30027) via MRI studies that there are small but significant differences between cis male and cis female brains, differences which align with the gender identities of trans people in the study. Note, **this does not mean that anyone with those differences will have that gender**, because gender identity isn’t that simple, but it provides evidence that there is a clear difference in masculine and feminine brains.
It [has been confirmed multiple times](https://www.the-scientist.com/features/are-the-brains-of-transgender-people-different-from-those-of-cisgender-people-30027) via MRI studies that there are small but significant differences between cis male and cis female brains, differences which align with the gender identities of trans people in the study. Note, **this does not mean that anyone with those differences will have that gender**, because gender identity isn't that simple, but it provides evidence that there is a clear difference in masculine and feminine brains. [There is also evidence](https://www.pnas.org/content/112/50/15468) that brains can have mosaic combinations of these differences, which may be the case in non-binary people.
A change in the testosterone levels in the fetus after the 11th week can directly impact the masculinization of the cerebral cortex, as well as changes in other parts of the brain structure. This has been examined [over and over again](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350266/) in studies of female assigned children with CAH (congenital adrenal hyperplasia) and CAIS (complete androgen insensitivity syndrome).
<blockquote class="cite"><p>We found a significant relationship between fetal testosterone and sexually differentiated play behavior in both girls and boys.</p>&mdash; <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778233/">Fetal Testosterone Predicts Sexually Differentiated Childhood Behavior in Girls and in Boys</a></blockquote>
An excess of testosterone in the mother’s body during the second trimester can (and does) cause masculinization of the brain in an externally female fetus, and an interference in testosterone production or uptake can (and does) cause feminisation of an externally male fetus. This interference does not have to be external in origin, either. Any number of genetic traits can cause the brain to respond differently to testosterone.
An excess of testosterone in the mother’s body during the second trimester can (and does) cause masculinization of the brain in an externally female fetus, and an interference in testosterone production or uptake can (and does) cause feminization of the brain in an externally male fetus. This interference does not have to be external in origin, either. Any number of genetic traits can cause the brain to respond differently to testosterone.
A fairly large study of transgender individuals released in 2018 [found several key genes](https://academic.oup.com/jcem/article/104/2/390/5104458) which were statistically more likely to be longer among trans women (longer, as in having more repeated fragments). Individually these genes may not have an impact strong enough to cause a malfunction of masculinization, but collectively they absolutely could reduce the ability for the fetal brain to masculinize. These genes are all passed from parent to child, giving credence to a tendency for trans parents to have trans children.
#### Gender is Biological
Sadly, western society has actively prevented a deeper understanding of gender. Ancient civilizations understood it well, but colonialism wiped them off the map. 100 years ago, [scientists in Germany were actively studying](https://en.wikipedia.org/wiki/Institut_f%C3%BCr_Sexualwissenschaft) transgender medicine and made extraordinary advancements, until the nazis burned it all in 1933. Conservative and fascist pressures in the modern day have hindered advancements in transgender healthcare whenever possible.
Sadly, western society has actively prevented a deeper understanding of gender. Ancient civilizations understood it well, but colonialism wiped them off the map. 100 years ago, [scientists in Germany were actively studying](https://en.wikipedia.org/wiki/Institut_f%C3%BCr_Sexualwissenschaft) transgender medicine and made extraordinary advancements, until the Nazis burned it all in 1933. Conservative and fascist pressures in the modern day have hindered advancements in transgender healthcare whenever possible.
Yet, progress continues, and every few years we learn a little bit more.
What we know for certain is that it is not a psychological condition, it is not something caused by trauma or by any external influence, nothing can make a person transgender. It happens in the womb, and is not something that a person can choose to be, any more than they could choose their race or their eye color. It has nothing to do with sexual orientation, it has nothing to do with kinks or fetishes, it has nothing to do with social influences from their parents or from their peers. [Transgender children are as firm in their identities as cisgender children are.](https://www.forbes.com/sites/dawnstaceyennis/2020/12/29/study-transgender-children-recognize-their-authentic-gender-at-early-age-just-like-other-kids/#20bbb14526bf).
What we know for certain is that it is not a psychological condition, it is not something caused by trauma or by any external influence, nothing can make a person transgender. It happens in the womb, and is not something that a person can choose to be, any more than they could choose their race or their eye color. It has nothing to do with sexual orientation, it has nothing to do with kinks or fetishes, and it has nothing to do with social influences from their parents or from their peers. [Transgender children are as firm in their identities as cisgender children are](https://www.forbes.com/sites/dawnstaceyennis/2020/12/29/study-transgender-children-recognize-their-authentic-gender-at-early-age-just-like-other-kids/#20bbb14526bf).